TRANSLATIONAL PHYSIOLOGY Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart
نویسندگان
چکیده
Sharon Judge, Young Mok Jang, Anthony Smith, Colin Selman, Tracey Phillips, John R. Speakman, Tory Hagen, and Christiaan Leeuwenburgh Biochemistry of Aging Laboratory, Genomics and Biomarkers Core of the Institute on Aging, Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, Florida; Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon; Department of Medicine (Centre for Diabetes and Endocrinology), University College London Centre for Research on Ageing, London, United Kingdom; and Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, and Division of Energy Balance and Obesity, Rowett Research Institute, Bucksburn, Aberdeen, Scotland, United Kingdom
منابع مشابه
Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart.
Evidence suggests that mitochondrial dysfunction and oxidant production, in association with an accumulation of oxidative damage, contribute to the aging process. Regular physical activity can delay the onset of morbidity, increase mean lifespan, and reduce the risk of developing several pathological states. No studies have examined age-related changes in oxidant production and oxidative stress...
متن کاملExercise during adolescence attenuated depressive-like behaviors and hippocampal mitochondrial dysfunction following early life stress in adult male rats
Purpose: In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have protective effects against early life stress (ELS) which can impact on behavior and mitochondrial function. Evidence indicates that ELS has deleterious effects on brain and behavior and increases the risk of mental disorders such as depressi...
متن کاملExercise during adolescence attenuated depressive-like behaviors and hippocampal mitochondrial dysfunction following early life stress in adult male rats
Purpose: In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have protective effects against early life stress (ELS) which can impact on behavior and mitochondrial function. Evidence indicates that ELS has deleterious effects on brain and behavior and increases the risk of mental disorders such as depressi...
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